ALTERNATIVE THERAPIES FOR CANINE CANCER
First, please discuss everything with your vet. Caring for a dog
with cancer must be teamwork. If youíre working with a holistic
veterinarian, then perhaps a lot of this information is already
known to him/her; that saves a step. If youíre working with your
regular vet, you may have to educate him/her to some new ideas.
Most vets are totally open to learning about new ways of treating an
old enemy so donít hesitate to open discussions.
surgical procedures that are available should be used to remove
primary tumors since it is the primary tumor that can send out seeds
for metastasis. Other cancers like leukemia, lymphoma and
hemangiosarcoma are usually cancers of the blood, lymph system or
blood vessels, which make it more difficult to locate and remove a
primary growth. In these cases, itís probably not going to be
operable but that does not translate to hopeless.
goal with most alternative cancer therapies is to induce apoptosis.
Apoptosis is a genetic program in all of us, and our dogs, that
tells cells itís their time to go. Apoptosis is regulated by the
P53 tumor suppressor gene (the gene has been directly linked to
osteosarcoma and hemangiosarcoma in studies done with Rottweilers).
A mutation occurs in this process that allows mutant cells to grow
out of control and that is cancer. The different names of cancers
are usually given to the type of tissue, area of the body, or system
that harbors the mutant cells. For example, mast cell cancer forms
from mast cells which are naturally occurring cells in the body,
spindle cell carcinoma derives from naturally occurring spindle
cells etc. Iím making this as simple as possible but it is far more
complex in reality.
Avemar is derived from fermented wheat germ; it comes in powder
formóin packets for humans. The results of studies show it greatly
improves survival and quality of life. There are no gastric side
effects with the exception of a possible soft stool periodically;
but with Avemar, there is no fear of intestinal necrosis. Itís too
new to say with certainty that it would be suitable for prevention
of cancer in a cancer prone line or breed, but I cannot see why not
since it does not damage healthy cells. It is an immune modulator
which is important for overall health. We know that cancer is also
an immune system failure.
Avemar originated in Hungary. The company
manufactures an identical supplement for pets called ImmunoVet but
it was not available in the United States until March 2012 when the
company began working with an American company to import the
veterinary form of Avemar.
Avemar is derived from the germ (endosperm, or
seed) of the wheat plant, and is a by-product of milling of wheat
kernels to produce flour. It differs from ordinary wheat germ in
that it is fermented to concentrate the substituted benzo-quinones,
which are biologically active. Concentration allows the
immunomodulatory effects of the substituted benzo-quinones to be
obtained without the consumption of impractically large amounts of
wheat germ. The fermented wheat germ product produced is then
treated with ionizing energy to reach the appropriate
product is rich in macro- and microelements, vitamins and
unsaturated fatty acids. Its important components include herbal
benzoic- and hydroquinones which have immune modulating and
antimicrobial effects Avemar
is manufactured in the same technological way as Immunovet during the
production of the active substances; the two production lines
separate during the solidification or drying steps. Avemar contains
mainly the water soluble particles of the biologically active
substances, and Immunovet contains the water
soluble part AND the solid parts as well. If we look only at the
raw production method, then Immunovet may
contain more types of the useful molecules than does Avemar. This
tells us a lot about the ingredients. The raw materials are mainly
identical to Avemar but Immunovet gets some
flaked corn during the drying and standardizing process which acts
as a carrier. Technically, this makes it a totally different product
does Immunovet work?
Immunovet helps in immune system defenses. The
product has a complex biological effect which affects both the
humoral and cellular immune systems.
mutated genes in cancer cells constantly urge these malignant cells
to divide. In order to maintain the processes of rapid cell
division, the cell metabolism must also be changed; the cell needs
to adapt nucleic acids (RNA/DNA) and other constituents for its own
use. Cancer cells adapt their metabolism to gain energy in a way
that enables them to utilize the most abundant resource in
circulation: glucose. (This is why so many ďcancer dietsĒ are
based on no carbohydrates and no sugars.). In order to maintain a
continuous proliferation, it is crucial that glucose is utilized
continuously for synthetic (anabolic) biochemical processes.
cells easily adapt to this glucose-based metabolism and are capable
of taking up and using enormous quantities of this molecule - up to
20-30 times more than normal cells. One part of glucose is
used by cancer cells for energy production, while another part will
be used for the synthesis of nucleic acids, which are the building
blocks of RNA and DNA.
make a very complex group of processes simple for us lay people, the
way Immunovet works is to decrease the
glucose-uptake of tumor cells in a dose-dependent manner and inhibit
the production of ribose and deoxyribose, a sugar that is the
backbone of DNA. It also inhibits key enzymes that cancer cells
need to grow. Further, Immunovet enhances
TNFalpha (tumor necrosis factor alpha) production, thereby
inhibiting tumor angiogenesis. Angiogenesis is the ability of
cancer cells to keep itself well supplied with blood. It
produces an enzyme that tells the circulatory system to send up more
circulation or blood supply. A lot of research in the States
has been focused on anti-angiogenesis but Immunovet
works on many fronts which makes it a more powerful weapon. Think of
cancer as an evil entity that circumvents the natural processes in
the body to establish an evil empire which builds itself into a
monster! Immunovet deconstructs cancer cells
by working on many of these processes, turning them back into what
they were before the onslaught of cancer which took control and
cleverly used these natural processes to grow itself at an enormous
Immunovet also has an immune modulating effect by
exerting a selective inhibition of MHC-I (major histo-compatibility-I)
expression on the surface of tumor cells. Immunovet
seems to restore the immune system to its pre-damaged condition. The
MHC genes are responsible for regulating antibody recognition which
means Immunovet is useful in autoimmune
diseases, as well. In Akitas, the MHC area of genes has been
shown to be abnormal with 70% of Akitas prone to autoimmune
diseases. This study was done at UC Davis in the the 1990s.
Using Immunovet for prevention may also aid in
preventing the onset of autoimmune diseases but keep in mind that
overall health is controlled not by one supplement but with a life
style change that includes fewer vaccines, fewer chemicals and grain
free or raw food diets.
There have been hundreds of clinical studies with Avemar throughout
the world and more recently, in the United States. Many of these
studies showed that Avemar induces apoptosis or programmed cell
death of cancer cells after the first 24 hours of use. It also has
significant anti-inflammatory effects and supports detoxification,
aiding the body in disposing of the dead cancer cells and any toxins
formed in the process of apoptosis. For breast cancer, Avemar blocks
the estrogen that stimulates the growth of these cells. All in all,
Avemar is an increasingly important alternative treatment.
Results of cell studies, animal studies, and human clinical
trials focused on cancer show that Avemar has exhibited significant
anti-cancer effects in a broad variety of cancer types and also
positive effects in auto-immune diseases.
For information on the clinical trials with humans and Avemar,
www.avemar.com and follow the
links to find a list of studies available at the National Library of
immune-modulating ability makes it very useful for many treatments.
We are still discovering how it works on various body systems but so
far, it is used to assist in the treatment ofÖ
● Immune and autoimmune diseases.
● Benign and malignant tumors
● Skin diseases by increasing the efficiency of the therapy
infectious skin diseases.
● Allergic skin inflammation and increased wound healing by
helping to stop
the licking of itchy skin.
● Painful arthritis.
● Overall improvement of the physical condition, and quality
● Treatment of physically rundown animals.
● Aiding in the recovery after surgical operations.
● Reduces the harm done by stress.
The only known
side effects can be a soft stool but that is seen infrequently. No
other known other side effects have been noted.
It is used
in conjunction with all forms of chemotherapy and has been proven to
extend survival time and quality of life in human patients without
any side effects except a loose stool. It should not be taken at
the same time as vitamin C (allow a 2-hour window on either side of
Immunovet). Otherwise there are no
restrictions. Adding Omega 3 essential fatty acids in the form of
fish oil, preferably from wild caught fish, will enhance this
Immunovet is not a substitute for clinical oncology
treatment and medications. This product should be kept strictly out
of the reach of children!
Usage is also
not advised in cases of hereditary fructose intolerance or if there
is hypersensitivity to wheat.
and Usage of Immunovet powder
As an adjunct to cancer treatments, the dose is 2 grams per each 25
pounds of body weight. You can double that amount as necessary to
achieve a better immune system balance.
I am using this for prevention with my dogs by giving them one half
of the recommended therapeutic dose. See the website for dosing.
To join my Yahoo group on using Avemar for cancer, send an email to:
To order the veterinary form
of Avemar, called Immunovet and imported directly from Biropharma in
The next effective treatment is Artemisinin (Arte) which is an
extract from the wormwood plant. Arte is used successfully to treat
malaria throughout the world.
Cancer cells have the highest concentration of iron in their cells
because they need that iron to stimulate growth, get a good blood
supply going and eventually kill the host! Arte attacks cells with
the highest concentration of iron much like the malaria parasite
which also contains a lot of iron.
article appearing in Life Sciences in 2001 by Drs. Singh and
Lai at the University of Washington detailed the rapid and complete
destruction of a radiation-resistant breast cancer cell line in
vitro. The destruction occurred within 8 hours and had little
effect on normal cells.
Artemisinin has two semi-synthetic derivatives: Artesunate and
Artemether. A paper published in Oncology in 2001 described the
cytotoxic effects of Artesunate against a wide variety of cancers
including melanomas, breast, ovarian, leukemia and colon cancers.
The growth of all of these cancers was inhibited by 50%.
source for this combination of Arte and its derivatives is Wellcare
source for the high quality Arte used at Washington State University
is Holley Pharmaceuticals. Here is their website:
must be given on an empty stomach. Allow at least 3 hours to elapse
after feeding and then give the Arte; wait one hour before feeding
again. Holley Phamaceutical will advise you on dosage. I have a
140 pound dog that is on 300mg daily split into two or 150 mg twice
a day. Using fat helps the absorptionóI give the capsules with some
wild caught salmon oil gelcaps and in organic butter or frozen
with butyrex which further helps with absorption and is also
available from Holley. Here is information on that supplement:
Artemisinin has an extremely helpful Yahoo group with many people
using it. Success stories with bone cancer, leukemia and other
cancers are exciting to read about: These people answer questions
and support and guide each other.
more reading on Arte, visit these sites:
Neoplasene is a treatment available from Buck Mountain Botanicals.
I have never used it topically though there are many people who
have, but as an oral treatment it works this way: A small amount is
ingested with food twice a day. It circulates within the
bloodstream and attacks and kills the mutant cells wherever it finds
them. It takes over and induces apoptosis. Where the genetic
program has broken down, Neoplasene takes its place. There is some
controversy over its use because it is very powerful but it is also
very effective. You need to contact Dr. Terence Fox at Buck
Mountain Botanicals to discuss its use and dosage since it is his
treatment protocol. His phone number is 1-406-232-1185.
key to giving Neoplasene is to prep the stomach because it will
induce vomitingóit is an emetic. The vomiting is not terrible but
itís not going to help treat the cancer so prepping the stomach is
vital. You must also make certain a large amount of food and water
is present to make the Neoplasene absorbable. There is a sheet that
Iíve put together to help you. Itís called Diet for Neoplasene and
are two groups available online that you should join since everyone
on these groups is using Neoplasene and some of these stories will
fill your heart with joy!
The other group is even larger with a great many downloadable sheets
to help youóthere are over 400 people supporting each other.
Fox is firm in stating two prerequisites for using Neoplasene. (1)
absolutely no NSAIDS or other forms of anti-inflammatory medicines.
The reason is simpleóneoplasene heats up the cancer cells to destroy
them. By using an anti-inflammatory, you prevent the Neoplasene
from doing its job. You may notice that your dog seeks a cool place
after eating. Thatís why. By all means, use Tramadol for pain as
needed, or one of the homeopathic remedies, like Traumeel.
His next request is no other treatments should
be used when using Neoplasene. Because of this statement, you
really need to make certain you want to use Neoplasene and not use
the other mentioned treatments which work in different ways.
For decades, the word was out that something in cruciferous
vegetables protects animals from cancer; in 1992, scientists from
Johns Hopkins University identified the active constituent as a
chemical called sulforaphane. Broccoli
contains more sulforaphane than the other vegetables. The best
source of it comes from sprouts that have grown to the second leaf
stage; these seedlings contain between 10 to 100 times as much
sulforaphane as a full-grown broccoli.
date the sulforaphane research focusing on cancer has discovered
that this protection results from stimulation of the body's own
antioxidant and detoxification system, which is comprised of what
scientists call Phase 2 Enzymes. The enzymes eliminate
carcinogens from the body before they can cause DNA damage. This
action protects healthy cells from cancer triggering chemicals.
exciting from a cutting edge point of view is a paper in the March
2000 issue of Cancer Research which reported for the first
time that sulforaphane can cause cancer cells to self-destruct, that
it triggers programmed cell death or apoptosis.
Research that is more recent reports on the genetic mechanisms by
which these broccoli chemicals work. For example, a recent study on
breast cancer showed sulforaphane binding to mammary tissue after
just a single dose of broccoli sprouts.
Earlier studies from 1997 and 2000 demonstrated that sulforaphane
prevented carcinogens from triggering cancer in breast tissue.
Other benefits of this supplement include
increasing the liverís capacity to detoxify potential carcinogens.
Sulforaphane glucosinolate is the precursor of sulforaphane and
ONCOPLEX contains sulforaphane glucosinolate (SGS).
You, your family and your pets should all be taking Oncoplex and I
do not make a penny on this recommendation! You can order it online
at the following websites:
IP6 with INOSITOL
mentioned above in the discussion on Arte, tumor cells utilize iron
as a growth factor. Researchers are constantly searching for a drug
that would be able to attach to iron molecules and remove them from
the body, producing an effective anti-cancer drug, without harming
the patient. The chemotherapy drug, Adriamycin (doxorubicin), is an
iron binder, but comes with severe side effects, including heart
is a naturally occurring compound that chelates (attaches to) iron
without side effects. Inositol hexaphosphate (IP6), is found
naturally in seeds and bran; it selectively removes iron from
abnormal cells without side effects. You can learn more about the
effectiveness of this natural treatment here:
started Jazzie on IP6 with Inositol from Enzymatic Therapy. I
purchase it from The Vitamin Shoppe in my area. She is on 6
capsules twice a day.
Lastly, I have Jazzie on a program under Dr. Charles Loops, a
renowned veterinary homeopathic. He has her on cell salts and
special nosodes. The aim with homeopathy is to do not harm so
whatever decisions you make, I highly recommend a telephone consult
with Dr. Loops. Jazzie has been doing well with this program and
the other alternatives that we are now using. I would have a better
sense of security about treating her cancer if she were on
Neoplasene, but for this dog, it is not a safe treatment.
goal in fighting cancer was to make my beloved friend as comfortable
as possible and prolong her life. If we can turn cancer into a
chronic, manageable disease instead of a fatal disease, what more
can we ask?
you need to email me, please feel free. I totally understand the
gnawing fear that goes with a cancer afflicted pet. The feelings of
helplessness can be overwhelming.